

Annie suffers a severe abdominal cramp due to the ingested hair and underwent surgery to remove it. During a visit with her father, Sean discovers that Annie has been pulling her hair out and ingesting it (a stress reaction known as "Rapunzel Syndrome"). Things are made worse after Sean abruptly marries Teddy. In Season 6, Annie is now a teenager and is openly resentful against her parents after their separation. She is being operated on by Sean in the last scene. In the final episode of the season, Annie is seriously hurt by a car crash with Sean's friend Christian Troy when they are trying to escape the paparazzi. Sean, knowing Eden put her up to it, threatens Eden to stay away from her and him.

After a failed attempt at inducing bulimia, Eden encourages Annie to move onto "Plan C" the next day Sean gets a call from Julia saying Annie has been expelled from her school for being caught performing oral sex with the boy she has a crush on. She even asks Sean to perform liposuction on her, but he forbids it. Eden, under the guise of being a caring "older sister", encourages Annie to lose weight to attract the attention of a boy she likes. In Season 5, Annie is living with Julia, her new girlfriend Olivia Lord, and her sociopathic daughter Eden. She is taken away by her mother when Julia leaves for New York City towards the end of the season. Julia gives birth to a boy, Conor, and Annie is uncomfortable with him because of his handicap. Sean and Julia interpret this as mockery, and Julia forces Annie to throw out her toys after she alters their hands. Annie, in a sincere attempt to understand this birth defect, tapes her fingers together to understand how her brother would feel and alters her dolls to have the same appearance. In season 4, Annie learns her mother is going to give birth to a boy with ectrodactyly, a webbing of the fingers and toes. She is briefly taken away from Sean until further notice. She leads them to believe, unintentionally, that he may be physically abusive and that he has emotionally affected her.

In Season 3, Annie has to talk to Family Services about her father Sean's anger problem. Annie's friend's mother throws Annie a "Princess Menses" party and invites her friends to celebrate the passage to womanhood.

In Season 2, Annie, at the age of 8, starts puberty. Julia later kills the pet, and does not tell Annie. She also adopts the class pet gerbil, Frisky. Here she is shown as going back to school, allowing her mother Julia to go back to medical school. Ann Katherine McNamara is the daughter of Sean and Julia McNamara.Annie first appears on the show in the pilot episode.
